Volume 12, Issue 4 (12-2022)                   J Health Saf Work 2022, 12(4): 800-819 | Back to browse issues page

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Habibi P, Ostad S N, Heydari A, Monazzam M R, Rahimi Foroushani A, Ghazi-Khansari M et al . Diagnostic Biomarkers of Heat Stress Induced- DNA in Occupational Exposure: A Systematic Review. J Health Saf Work 2022; 12 (4) :800-819
URL: http://jhsw.tums.ac.ir/article-1-6772-en.html
1- Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2- Toxicology and Poisoning Research Centre, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Health in Disaster and Emergencies, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5- Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6- Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran , fgolbabaei@tums.ac.ir
Abstract:   (169 Views)
Introduction: Climate change and hot processes in the workplaces has led to an increase in the effects of heat stress on employed people, which has become a major concern, especially in tropical and subtropical countries. Early detection of biomarkers in induction of heat stress-related DNA damage can be used in the identification and evaluation of health and safety, including occupational health professionals, as well as to prevent serious diseases caused by heat stress in various occupations with the nature of hot processes or to help different warm seasons of the year. Therefore, this review study was conducted to identify diagnostic biomarkers heat stress induced- DNA damage in occupational exposure.
Material and Methods: Databases such as PubMed, Scopus, Google Scholar, and Web of Science were systematically searched to meet the study’s goals. Moreover, references to relevant publications were examined. Finally, suitable articles were selected and analyzed using the inclusion (studies on different occupations, different biomarkers in hot work environments, all articles published without time limit until the end of April 2022 , and English and Persian language)  and exclusion criteria.
Results: The results of search in databases showed that 9234 articles were found in the initial search. After removing duplicate and unrelated articles, 2209 eligible articles were selected. Based on abstract full-text screening, 7166 studies were excluded, and based on abstract full-text screening, 21 studies were not accessible. Finally, seven articles were selected to be reviewed. The evidence showed that diagnostic biomarkers included the measurement of 8-hydroxy-2-deoxyguanosine (8-OHdG), micronuclei semen quality, heat shock proteins (HSP70), and leukocytes were extracted to heat stress induced- DNA damage in occupational exposure.
Conclusion: Based on a review of studies,  biomarkers identified are suitable for heat stress induced- DNA damage as a result of occupational exposure to extremely high heat climate conditions. Understanding and identifying appropriate biomarkers in inducing DNA damage can help health and safety professionals determine the amount and magnitude of heat stress responses in occupational exposure to different temperatures and take appropriate measures and interventions to control and reduce the hazard effects of thermal stress. This study can also be considered as a preliminary study for research in the future.
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Type of Study: Review |
Received: 2022/12/26 | Accepted: 2022/12/31 | Published: 2022/12/31

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